The Emerald Coast has a few totally different vibes, and the best place to stay depends on what you're after. Here's the short version, then we'll dig in per area.
The hub of beach condos, resorts, the harbor and the boardwalk. If you want restaurants and boat trips on your doorstep, this is it. See the Destin hub.
A big resort area with the Sandestin community, Baytowne Wharf and easy beach access. Miramar walks a line between beach and resort-town amenities. Great all-rounder.
Laid-back coastal towns like Seaside, Grayton, WaterColor and Seagrove. More charm, more cottages, a totally different, slower rhythm. See the 30A hub.
Sandestin resorts or Destin condos, easy beach access + pools.
30A cottages in Seaside or Grayton.
Stay near Destin Harbor or Crab Island launch points.
Miramar Beach and north of the highway for more value.